Folium Anthrisci sylvestris
Aliases：E Shen Ye; E Shen Cai Ye.
E Shen Ye (Anthriscus Leaf) is the name of a traditional Chinese medicine. It is the leaf of Anthriscus sylvestris (L.) Hoffm., a plant in the family Apiaceae (Umbelliferae). It is a commonly used folk medicine for external application and is recorded in Hunan Materia Medica, Sichuan Materia Medica, Chinese Materia Medica, and other herbal works.
Efficacy & Actions
Stops bleeding and reduces swelling.
Indications
Traumatic bleeding; swelling and pain.
Modern Pharmacology
Modern pharmacological studies have confirmed that the aqueous extract of Anthriscus leaves (AE-ASL) exhibits the following significant pharmacological activities: Anti-inflammatory effect: AE-ASL significantly inhibited the secretion of nitric oxide (NO) and prostaglandin E₂ (PGE₂) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and dose-dependently reduced the mRNA and protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory mediators such as TNF-α, IL-1β, and IL-6. The mechanism involves the inhibition of nuclear translocation of the NF-κB p65 subunit and the phosphorylation of MAPK. In the carrageenan-induced rat paw edema model, oral administration (50, 100, and 200 mg/kg) resulted in edema inhibition rates of 15%, 31%, and 40%, respectively, after 4 hours. Chondroprotective effect: AE-ASL significantly inhibited IL-1β-induced expression of nitrite, PGE₂, iNOS, COX-2, MMP-3, MMP-13, and ADAMTS-4 in rat primary chondrocytes. The mechanism is related to the inhibition of the MAPK and NF-κB signaling pathways. In a DMM surgery-induced osteoarthritis rat model, oral administration for 8 weeks significantly inhibited cartilage destruction, suggesting that Anthriscus Leaf has the potential to delay the progression of osteoarthritis.
Ingredients
Anthriscus Leaf mainly contains the following active constituents: Volatile components: (-)-Sabinene (sabinene) is the principal constituent. The essential oil contains more than ten compounds, including phenol, cresols (o-, m-, and p-cresol), and guaiacol. Lignans: Deoxypodophyllotoxin, which exhibits antitumor, antiproliferative, antiplatelet aggregation, antiviral, anti-inflammatory, and insecticidal activities. Sterols: Stigmasterol and β-sitosterol. Others: n-Paraffins and n-alcohols.
Usage & Dosage
External use: Appropriate amount. Fresh material is pounded and applied topically; dried material is ground into powder and sprinkled on the affected area or mixed into a paste for topical application.
Contraindications
This product is for external use and is generally not to be taken orally.
Selected Formulas
For traumatic swelling and pain (Hunan Materia Medica) Take fresh E Shen leaves, crush them; or grind dried leaves into powder, mix with water, and apply. For traumatic bleeding (Sichuan Chinese Materia Medica, 1979 edition) Take fresh E Shen leaves, crush into a pulp; or grind dried leaves finely, and apply to the affected area.
Medicinal Parts
Leaf.
Selection & Storage
Dried material should be stored in a well-ventilated, dry place. Protect from moisture and insect damage. Fresh material should be used promptly or refrigerated for short-term storage.
